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Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The zymogenic form of protein C is a vitamin K-dependent glycoprotein which circulates in blood plasma. Because of the crucial role that protein C plays as an anticoagulant, those with either deficiencies in protein C, or some kind of resistance to Activated protein C (APC), suffer from a significantly increased risk of forming dangerous blood clots (thrombosis).
- Artifactually decreased functional protein C values may be seen in patients with abnormally elevated levels of factor V111
- Artifactually increased levels of functional protein C values may be seen in patients on heparin therapy
- Patients on oral anti coagulants will have decreased functional protein C values. Patients should be off oral anticoagulant therapy for two weeks for accurate measurement of functional protein C levels.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions.