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Vitamin B12, a member of the corrin family of compounds, is implicated in the formation of myelin and along with Folate, is required for DNA synthesis. The most prominent source of B12 for humans is meat, while untreated fresh water can also be a source.
Upto 40-50% of serum corrins may be physiologically inactive 12 analogues. These analogues serve no useful function and may compete with B12 binding capacity. The archetypical analogue, combinamide, is not bound by the primary binding protein specific for ideal B12 uptake.
Megaloblastic Anaemia, characterized by elevated MCV, has been found to be due to B12 defeciency, a
major cause being pernicious Anemia due to poor B12 uptake resulting in below normal serum levels.
Other conditions related to low B12 include iron deficiency, normal near term pregnancy, vegetarianism, partial gastrectomy, ileal damage, oral contraceptives, parasitic infestation, pancreatic deficiency, treated epilepsy and advancing age. The correlation of serum B12 levels and magloblastic anemia, however, is not always clear. Some patients with high MCV may have normal B12 levels, while some individuals with B12 deficiency may not have magloblastic anemia.
Disorder like renal failure, liver disease and myeloproliferative diseases may have elevated vitamin B12 levels.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions.